Scandinavian Simvastatin Survival Study (4S) - 1994
Improving lipid levels in people with heart disease and above average cholesterol levels.

West of Scotland Coronary Prevention Study (WOSCOPS) - 1995
Improving lipid levels in people with no heart disease and above average cholesterol levels.

Cholesterol and Recurrent Events (CARE) - 1995
Improving lipid levels in people with heart disease and average cholesterol levels.

Long-term Intervention with Pravastatin in Ischaemic Disease
(LIPID) - 1998
Improving lipid levels in people with heart disease and average cholesterol levels.

Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) - 1998
Lowering LDL & raising HDL in people with no heart disease & average cholesterol levels.

MCR/BHF Heart Protection Study (HPS) - 2002
HPS enrolled 20,000 patients whose risk of heart disease was statistically high, but for whom there was little direct evidence that statins would be beneficial.